Killing IE, if possible, else a hard reboot seemed the only options.
I got a weird call from another tech saying that a user’s Internet Explorer was opening multiple tabs, over and over again, until the system came to a crawl because it was running out of memory.
Turns out that a new “feature” that you didn’t ask for is the cause. We had a recent spate of Internet Explorer opening multiple tabs to the point of exhausting computer memory, and it seemed exclusively Windows 10 boxes.